Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH and PI3K-AKT pathways intertwined.

Cancer cell - 1 Nov 2007

Gutierrez Alejandro, Look A Thomas

Abstract excerpt

Constitutive signaling by the NOTCH1 receptor contributes to more than half of all cases of T cell acute lymphoblastic leukemia (T-ALL). However, blocking the proteolytic activation of NOTCH1 with gamma-secretase inhibitors (GSIs) fails to alter the growth of some T-ALL cell lines carrying the mutated receptor. A recent report by Palomero et al. in Nature Medicine identifies loss of PTEN as a critical event...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Enzymologic
Share to Gene Expression Regulation, Neoplastic
Share to Leukemia, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oncogenes

Share to Phosphatidylinositol 3-Kinases

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Notch1

Source

Identifiers

PMID: 17996644
DOI: 10.1016/j.ccr.2007.10.027

Genes

NOTCH1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH and PI3K-AKT pathways intertwined.PMID 17996644Read ↗

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.Semantic proximity Read ↗

Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas.Semantic proximity Read ↗

The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Recent advances on NOTCH signaling in T-ALL.Semantic proximity Read ↗

Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disordersSemantic proximity Read ↗

PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.Semantic proximity Read ↗

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines.Semantic proximity Read ↗

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screenSemantic proximity Read ↗

The role of NOTCH1 signaling in T-ALL.Semantic proximity Read ↗

The multifaceted role of Notch in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.