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Current understanding of cancer-intrinsic PD-L1: regulation of expression and its protumoral activity

31 Jan 2021

Abstract excerpt

In the last decade, we have witnessed an unprecedented clinical success in cancer immunotherapies targeting the programmed cell-death ligand 1 (PD-L1) and programmed cell-death 1 (PD-1) pathway. Besides the fact that PD-L1 plays a key role in immune regulation in tumor microenvironment, recently a plethora of reports has suggested a new perspective of non-immunological functions of PD-L1 in the regulation of...

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PMID: 33298250
DOI: 10.5483/bmbrep.2021.54.1.241

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