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NKG2D and MICA/B shedding: a ‘tag game’ between NK cells and malignant cells

1 Jan 2020

Abstract excerpt

Natural killer (NK) cells are innate lymphocytes with cytotoxic functions and recognise target cells with the NK group 2D (NKG2D) receptor. Tumor cells are marked for NK-cell-mediated destruction upon expression of MICA and MICB (MICA/B), which are NKG2D ligands upregulated by many human cancers in response to cellular stress pathways associated with malignant transformation such as DNA damage and accumulation of...

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PMID: 33363734
DOI: 10.1002/cti2.1230

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