Article

Esophageal epithelial <i>Ikkβ</i> deletion promotes eosinophilic esophagitis in experimental allergy mouse model

2024-07-10

Abstract excerpt

<h4>Background</h4> Eosinophilic esophagitis (EoE) is a chronic T helper type 2 (Th2)-associated inflammatory disorder triggered by food allergens, resulting in esophageal dysfunction through edema, fibrosis, and tissue remodeling. The role of epithelial remodeling in EoE pathogenesis is critical but not fully understood. <h4>Objective</h4> To investigate the role of epithelial IKKβ/NFκB signaling in EoE pathoge...

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Literature Corpus work: da6fafb2-8680-557a-a603-31a79614e711
DOI: 10.1101/2024.07.05.602313

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