Article

The variation landscape of <i>CYP2D6</i> in a multi-ethnic Asian population

2024-01-23

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) plays a crucial role in metabolizing approximately 20% of medications prescribed clinically. This enzyme is encoded by the CYP2D6 gene, known for its extensive polymorphism with over 170 catalogued haplotypes or star alleles, which can have a profound impact on drug efficacy and safety. Despite its importance, a gap exists in the global genomic databases, which are predominantly repre...

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Literature Corpus work: da6f1ece-13c4-5d95-a38b-7f709a4958f2
DOI: 10.1101/2024.01.20.576401

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