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Article

Characterization of CYP2D6 Pharmacogenetic Variation in Sub-Saharan African Populations.

Clinical pharmacology and therapeutics - 1 Mar 2023

Twesigomwe David, Drögemöller Britt I, Wright Galen E B, Adebamowo Clement, Agongo Godfred, Boua Palwendé R, Matshaba Mogomotsi, Paximadis Maria, Ramsay Michèle, Simo Gustave, Simuunza Martin C, Tiemessen Caroline T, Lombard Zané, Hazelhurst Scott

Abstract excerpt

Cytochrome P450 2D6 (CYP2D6) is a key enzyme in drug response owing to its involvement in the metabolism of ~ 25% of clinically prescribed medications. The encoding CYP2D6 gene is highly polymorphic, and many pharmacogenetics studies have been performed worldwide to investigate the distribution of CYP2D6 star alleles (haplotypes); however, African populations have been relatively understudied to date. In this...

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Identifiers

PMID: 36111505
DOI: 10.1002/cpt.2749
PMCID: PMC9957841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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