Article

Anonymized Somatic Tumor Twins (STTs) enable open genome data sharing and use in research and clinical oncology

2026-04-03

Abstract excerpt

The study of somatic variants from tumor genomes is fundamental to cancer research and clinical decision-making. However, existing data protection frameworks impose restrictions on the use and sharing of these variants in conjunction with sensitive germline information. To overcome these challenges, we developed GenomeAnonymizer, the first method to anonymize short-read DNA sequences from tumor-normal pairs. This...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da6c0d05-e0a5-5b00-beea-d21123c5335a
DOI: 10.64898/2026.04.01.715771

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anonymized Somatic Tumor Twins (STTs) enable open genome data sharing and use in research and clinical oncologyDOI 10.64898/2026.04.01.715771Read

Landscape of human protein-coding somatic mutations across tissues and individualsSemantic proximity Read

A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal.Semantic proximity Read

The emerging significance of secondary germline testing in cancer genomics.Semantic proximity Read

Evaluating somatic tumor mutation detection without matched normal samples.Semantic proximity Read

Precise identification of somatic and germline variants in the absence of matched normal samples.Semantic proximity Read

Germline Contamination and Leakage in Whole Genome Somatic Single Nucleotide Variant DetectionSemantic proximity Read

Germline contamination and leakage in whole genome somatic single nucleotide variant detection.Semantic proximity Read

SomaticSniper: identification of somatic point mutations in whole genome sequencing data.Semantic proximity Read

Clinical application of tumour-in-normal contamination assessment from whole genome sequencingSemantic proximity Read

ONCOLINER: A new solution for monitoring, improving, and harmonizing somatic variant calling across genomic oncology centers.Semantic proximity Read

Joint analysis of matched tumor samples with varying tumor contents improves somatic variant calling in the absence of a germline sampleSemantic proximity Read

Target-enhanced whole-genome sequencing (TE-WGS) shows clinical validity equivalent to commercially available targeted oncology panelSemantic proximity Read