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Article

The emerging significance of secondary germline testing in cancer genomics.

The Journal of pathology - 1 Apr 2018

Mandelker Diana, Zhang Liying

Abstract excerpt

Many clinical laboratories now sequence the tumors from advanced cancer patients to identify oncogenic drivers and guide targeted therapies and clinical trials. One limitation of tumor sequencing is that it cannot distinguish between tumor-specific somatic (acquired) mutations and patients' germline (constitutional) variants. To definitively identify somatic variants, some clinical labs sequence both a normal...

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PMID: 29293272
DOI: 10.1002/path.5031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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