Article

Ataxin-2 Binds Alpha-Actinin-1

2019-11-30

Abstract excerpt

Ataxin-2 (human gene symbol ATXN2, protein ATXN2) is the disease protein of Spinocerebellar Ataxia type 2 (SCA2). The large expansions of a polyglutamine (polyQ) stretch above a threshold of ~33 glutamines cause the multi-system nervous atrophy SCA2, while intermediate expansions of 29-32 glutamines contribute to the risk of the motor neuron diseases Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Lobar De...

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Literature Corpus work: 621d3ce0-3fce-5bbc-bedb-95047e0b3ac0
DOI: 10.20944/preprints201911.0399.v1

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