Article

Fibrinogen signalling in human iPSC-derived microglia

2024-05-06

Abstract excerpt

<title>Abstract</title> <p>In Alzheimer’s disease (AD) and multiple sclerosis (MS), microglia are exposed to the blood protein fibrinogen (FG), and we showed previously the response of primary-cultured rat microglia to FG. Here, we show human iPSC-derived microglia (iPS-Mg) respond to FG, inducing secretion of a range of cytokines and chemokines and activation of stress pathways. An increased pro-caspase 4/5 (and...

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Literature Corpus work: da578e80-bd70-53c7-a6e2-35865f5ffd96
DOI: 10.21203/rs.3.rs-4324378/v1

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