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Article

COVID-19 inactivated and non-replicating viral vector vaccines induce regulatory training phenotype in human monocytes under epigenetic control.

Frontiers in cellular and infection microbiology - 1 Jan 2023

Antunes Mateus da Silva Matias, Sugiyama Fabricia Heloisa Cavicchioli, Gravina Humberto Doriguetto, Castro Ricardo Cardoso, Mercado Francisco Javier Romero, de Lima Julia Oliveira, Fontanari Caroline, Frantz Fabiani Gai

Abstract excerpt

Background: Trained immunity is the enhanced innate immune response resulting from exposure to pathogens or vaccines against an unrelated pathogen stimulus. Certain vaccines induce a memory like response in monocytes and NK cells, leading to modulation in cytokine production, metabolic changes, and modifications in histone patterns. Here, we hypothesized that vaccination against SARS-CoV-2 could induce the...

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Identifiers

PMID: 37520439
DOI: 10.3389/fcimb.2023.1200789
PMCID: PMC10382685

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