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Multi-omics delineation of cytokine-induced endothelial inflammatory states

15 May 2023

Abstract excerpt

Vascular endothelial cells (ECs) form a dynamic interface between blood and tissue and play a crucial role in the progression of vascular inflammation. Here, we aim to dissect the system-wide molecular mechanisms of inflammatory endothelial-cytokine responses. Applying an unbiased cytokine library, we determined that TNFα and IFNγ induced the largest EC response resulting in distinct proteomic inflammatory...

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PMID: 37188730
DOI: 10.1038/s42003-023-04897-w

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