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Article

Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth.

Cell reports - 21 Jul 2020

Balakrishnan Mridula, Yu Shannon F, Chin Samantha M, Soffar David B, Windner Stefanie E, Goode Bruce L, Baylies Mary K

Abstract excerpt

Sarcomeres, the fundamental contractile units of muscles, are conserved structures composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed and maintained is not well understood. Here, we show that knockdown of Drosophila cofilin (DmCFL), an actin depolymerizing factor, disrupts both sarcomere structure and muscle function. The loss of DmCFL also results in the formation of...

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Identifiers

PMID: 32697999
DOI: 10.1016/j.celrep.2020.107893
PMCID: PMC7479987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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