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Article

Exploiting biological priors and sequence variants enhances QTL discovery and genomic prediction of complex traits.

BMC genomics - 27 Feb 2016

MacLeod I M, Bowman P J, Vander Jagt C J, Haile-Mariam M, Kemper K E, Chamberlain A J, Schrooten C, Hayes B J, Goddard M E

Abstract excerpt

BACKGROUND: Dense SNP genotypes are often combined with complex trait phenotypes to map causal variants, study genetic architecture and provide genomic predictions for individuals with genotypes but no phenotype. A single method of analysis that jointly fits all genotypes in a Bayesian mixture model (BayesR) has been shown to competitively address all 3 purposes simultaneously. However, BayesR and other similar...

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PMID: 26920147
DOI: 10.1186/s12864-016-2443-6
PMCID: PMC4769584

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