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Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in <i>Schistosoma mansoni</i>

2019-11-04

Abstract excerpt

Treatment and control of schistosomiasis still rely on only one effective drug, praziquantel (PZQ), and due to mass treatment, the increasing risk of selecting for schistosome strains that are resistant to PZQ has alerted investigators to the urgent need to develop novel therapeutic strategies. The histone-modifying enzymes (HMEs) represent promising targets for the development of epigenetic drugs against Schisto...

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Literature Corpus work
d9e78cdc-60e7-5029-a4b4-785bfa398ef0
DOI
10.1101/829549
Open publication

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Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in <i>Schistosoma mansoni</i>DOI 10.1101/829549
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