Article

Schistosomes alter expression of immunomodulatory gene products following <i>in vivo</i> praziquantel exposure

2020-01-23

Abstract excerpt

Control of the neglected tropical disease schistosomiasis relies almost entirely on praziquantel (PZQ) monotherapy. How PZQ clears parasite infections remains poorly understood. Many studies have examined the effects of PZQ on worms cultured in vitro , observing outcomes such as muscle contraction. However, conditions worms are exposed to in vivo may vary considerably from in vitro experiments given the short h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4ba7d9dc-7256-5f2c-9d98-f31c0ec44b81
DOI: 10.1101/2020.01.22.915710

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Schistosomes alter expression of immunomodulatory gene products following <i>in vivo</i> praziquantel exposureDOI 10.1101/2020.01.22.915710Read

Transcriptome of the parasitic flatworm <i>Schistosoma mansoni</i> during intra-mammalian developmentSemantic proximity Read

The transcriptome of <i>Schistosoma mansoni</i> developing eggs reveals key mediators in pathogenesis and life cycle propagationSemantic proximity Read

Transcriptome analysis of peripheral blood of <i>Schistosoma mansoni</i> infected children from the Albert Nile region in Uganda reveals genes implicated in fibrosis pathologySemantic proximity Read

Artemisitene protected against murine schistosomiasis japonica through anti-parasite activity and immune regulationSemantic proximity Read

Transcriptional phenotype of the anti-parasitic benzodiazepine meclonazepam on the blood fluke <i>Schistosoma mansoni</i>Semantic proximity Read

The Transcriptome of Schistosoma mansoni Developing Eggs Reveals Key Mediators in Pathogenesis and Life Cycle PropagationSemantic proximity Read

Imatinib Treatment Causes Substantial Transcriptional Changes in Adult Schistosoma mansoni In Vitro Exhibiting Pleiotropic EffectsSemantic proximity Read

Gene expression changes in mammalian hosts during schistosomiasis: a reviewSemantic proximity Read

Large-scale RNAi screening uncovers new therapeutic targets in the human parasite <i>Schistosoma mansoni</i>Semantic proximity Read

Chemical modulation of Schistosoma mansoni lysine specific demethylase 1 (SmLSD1) induces wide-scale biological and epigenomic changesSemantic proximity Read

Transcriptome of the parasitic flatworm Schistosoma mansoni during intra-mammalian developmentSemantic proximity Read

Single-cell atlas of the first intra-mammalian developmental stage of the human parasite <i>Schistosoma mansoni</i>Semantic proximity Read