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A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in <i>Schistosoma mansoni</i>

2025-03-15

Abstract excerpt

Schistosomes are parasitic flatworms that infect more than 200 million people globally. However, there is a shortage of molecular tools that enable the discovery of potential drug targets within schistosomes. Thus, praziquantel has remained the frontline treatment for schistosomiasis despite known liabilities. Here, we have conducted a genome-wide study in S. mansoni using the human druggable genome as a bioinfor...

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Literature Corpus work
953ee1b6-ff27-5dbf-8bb9-08e61f06464a
DOI
10.1101/2025.03.14.643303
Open publication

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A genome-scale drug discovery pipeline uncovers new therapeutic targets and a unique p97 allosteric binding site in <i>Schistosoma mansoni</i>DOI 10.1101/2025.03.14.643303
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