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Article

Drugging the Schistosome Zinc-Dependent HDACs: Current Progress and Future Perspectives

1 Apr 2015

Abstract excerpt

Schistosomes, like many eukaryotic pathogens, typically display morphologically distinct stages during their life cycles. Epigenetic mechanisms underlie the pathogens' morphological transformations, and the targeting of epigenetics-driven cellular programs therefore represents an Achilles' heel of parasites. To speed up the search for new antiparasitic agents, drugs validated for other diseases can be rationally...

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PMID: 25996070
DOI: 10.4155/fmc.15.25

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