Hydroxyurea for Children and Adults with Hemoglobin SC Disease

Abstract excerpt

BACKGROUND: Hemoglobin SC (HbSC) is a common sickle hemoglobinopathy that causes acute complications, chronic organ damage, and early death with no established disease-modifying treatment. In this trial, we examined the safety and efficacy of hydroxyurea treatment in patients with HbSC. METHODS: Prospective Identification of Variables as Outcomes for Treatment (PIVOT) was a double-blind, randomized,...

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