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Extrinsic and intrinsic drivers of natural killer cell clonality

20 Mar 2024

Abstract excerpt

Clonal expansion of antigen-specific lymphocytes is the fundamental mechanism enabling potent adaptive immune responses and the generation of immune memory. Accompanied by pronounced epigenetic remodeling, the massive proliferation of individual cells generates a critical mass of effectors for the control of acute infections, as well as a pool of memory cells protecting against future pathogen encounters....

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PMID: 38506411
DOI: 10.1111/imr.13324

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