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Article

Evolution of Cytomegalovirus-Responsive T Cell Clonality following Solid Organ Transplantation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2021

Higdon Lauren E, Schaffert Steven, Huang Huang, Montez-Rath Maria E, Lucia Marc, Jha Alokkumar, Saligrama Naresha, Margulies Kenneth B, Martinez Olivia M, Davis Mark M, Khatri Purvesh, Maltzman Jonathan S

Abstract excerpt

CMV infection is a significant complication after solid organ transplantation. We used single cell TCR αβ sequencing to determine how memory inflation impacts clonality and diversity of the CMV-responsive CD8 and CD4 T cell repertoire in the first year after transplantation in human subjects. We observed CD8 T cell inflation but no changes in clonal diversity, indicating homeostatic stability in clones. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Identifiers

PMID: 34551964
DOI: 10.4049/jimmunol.2100404
PMCID: PMC8492537

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