Article

Murine norovirus mutants adapted to replicate in human cells reveal a post-entry restriction

2024-01-11

Abstract excerpt

RNA viruses lack proofreading in their RNA polymerases and therefore exist as genetically diverse populations. By exposing these diverse viral populations to selective pressures, viruses with mutations that confer fitness advantages can be enriched. To examine factors important for viral tropism and host restriction, we passaged murine norovirus (MNV) in a human cell line, HeLa cells, to select for mutant viruses...

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Literature Corpus work: d9c69fdc-c983-5f08-97eb-8e97bceb670c
DOI: 10.1101/2024.01.11.575274

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