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Article

CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus

6 Apr 2020

Abstract excerpt

Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly.Viral receptor utilization is a major determinant of cell tropism, host range, and pathogenesis.The bona fide receptor for HNoV is unknown.Recently, we identified CD300lf as a proteinaceous receptor for MNoV.Interestingly, its paralogue CD300ld was also sufficient for MNoV infection in vitro.Here we...

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PMID: 32251490
DOI: 10.1371/journal.ppat.1008242

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