Article
High-throughput sequencing analysis reveals the genetic diversity of different regions of the murine norovirus genome during in vitro replication.
Archives of virology - 1 Apr 2017
Mauroy Axel, Taminiau Bernard, Nezer Carine, Ghurburrun Elsa, Baurain Denis, Daube Georges, Thiry Etienne
Abstract excerpt
In this study, we report the genetic diversity and nucleotide mutation rates of five representative regions of the murine norovirus genome during in vitro passages. The mutation rates were similar in genomic regions encompassing partial coding sequences for non-structural (NS) 1-2, NS5, NS6, NS7 proteins within open reading frame (ORF) 1. In a region encoding a portion of the major capsid protein (VP1) within...
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