Article

Demonstration of SLU7 as a new pan-cancer target

2025-08-29

Abstract excerpt

Cancer treatment remains challenging due to heterogeneous responses to immunotherapy across patients and tumor types. Innovative strategies are required to overcome immune evasion. We have identified the splicing factor SLU7 as essential for the survival of cancer cells from diverse origins. SLU7 knockdown induces R-loop accumulation, transcription-dependent genomic instability, DNA damage, and replication catastr...

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Identifiers and source

Literature Corpus work: d9c68fe9-487b-5161-9326-1684ee108b33
DOI: 10.1101/2025.08.25.672085

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