Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression

11 Jun 2025

Abstract excerpt

Background Hepatocellular carcinoma (HCC) is characterized by a complex interplay of genetic and epigenetic alterations that contribute to its aggressive nature and resistance to conventional therapies. The recent advent of immune checkpoint inhibitors has shown promise in enhancing the immune system's ability to target cancer cells. However, the efficacy of these therapies is often hindered by the tumor's...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Circular RNAs in diseases
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40568595
DOI: 10.3389/fimmu.2025.1609165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progressionPMID 40568595Read ↗

Circular RNAs as Targets for Developing Anticancer TherapeuticsSemantic proximity Read ↗

CircRNAs: functions and emerging roles in cancer and immunotherapySemantic proximity Read ↗

CircRNA Regulation of T Cells in Cancer: Unraveling Potential TargetsSemantic proximity Read ↗

Mechanisms of immune checkpoint inhibitors: insights into the regulation of circular RNAS involved in cancer hallmarksSemantic proximity Read ↗

The Roles of circRNAs in Liver Cancer ImmunitySemantic proximity Read ↗

Unveiling Pharmacogenomics Insights into Circular RNAs: Toward Precision Medicine in Cancer TherapySemantic proximity Read ↗

Elevated circASCC3 Suppresses Antitumor Immunity by Sponging miR-432-5p to Upregulate C5a in Non-small-cell Lung CancerSemantic proximity Read ↗

Circular RNA SPECC1 promoted tumorigenesis and osimertinib resistance in lung adenocarcinoma via a circular RNA-microRNA networkSemantic proximity Read ↗

CircRUNX1 Drives Immune Evasion and anti-PD1 Immunotherapy Resistance in Lung Adenocarcinoma by the miR-4739/PCSK9/MHC I AxisSemantic proximity Read ↗

Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretomeSemantic proximity Read ↗

CSF3R-AS promotes hepatocellular carcinoma progression and sorafenib resistance through the CSF3R/JAK2/STAT3 positive feedback loopSemantic proximity Read ↗

Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.