Article

Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy

2025-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor (CAR)-based immunotherapies against solid tumors face two major hurdles, the “decoy effect” of shedding antigens that sequester CARs, and the limited persistence of immune effectors within the immunosuppressive tumor microenvironment. Here, we present a mechanistic approach to overcome these barriers by integrating a physiologically relevant screening platform with circ...

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Identifiers and source

Literature Corpus work: c03898da-8023-5fbb-a234-d947f203746f
DOI: 10.1101/2025.08.19.671003

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