A genetic and molecular update on adrenocortical causes of Cushing syndrome.

Abstract excerpt

Primary adrenal Cushing syndrome is the result of cortisol hypersecretion mainly by adenomas and, rarely, by bilateral micronodular or macronodular adrenocortical hyperplasia. cAMP-dependent protein kinase A (PKA) signalling is the major activator of cortisol secretion in the adrenal cortex. Many adenomas and hyperplasias associated with primary hypercortisolism carry somatic or germline mutations in genes that...

Topics

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• Adrenal and Paraganglionic Tumors
• Adrenal Cortex
• Adrenal Hyperplasia, Congenital
• Cardiac tumors and thrombi
• Cushing Syndrome