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Article

A genetic and molecular update on adrenocortical causes of Cushing syndrome.

Nature reviews. Endocrinology - 1 May 2016

Lodish Maya, Stratakis Constantine A

Abstract excerpt

Primary adrenal Cushing syndrome is the result of cortisol hypersecretion mainly by adenomas and, rarely, by bilateral micronodular or macronodular adrenocortical hyperplasia. cAMP-dependent protein kinase A (PKA) signalling is the major activator of cortisol secretion in the adrenal cortex. Many adenomas and hyperplasias associated with primary hypercortisolism carry somatic or germline mutations in genes that...

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Identifiers

PMID: 26965378
DOI: 10.1038/nrendo.2016.24

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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