PRKACA Mutations in Adrenal Adenomas: Genotype/Phenotype Correlations.

Abstract excerpt

Untargeted, next generation sequencing approaches have provided deep insights into genetic events that result in unopposed steroidogenesis from the adrenal cortex. In particular, somatic mutations in the gene encoding the catalytic subunit α of protein kinase A (PKA) (PRKACA) were identified independently by several groups as the most frequently altered gene in cortisol-producing adenomas. Detailed functional...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adrenal Cortex Neoplasms
• Share to Adrenocortical Adenoma