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Article

Functional diversification of the toll-like receptor gene family.

Immunogenetics - 1 May 2008

Hughes Austin L, Piontkivska Helen

Abstract excerpt

Phylogenetic analyses supported the hypothesis that the vertebrate toll-like receptors (TLRs) include two very ancient groups that arose by gene duplication prior to the divergence of protostomes and deuterostomes: (1) the TLR1 family (including mammalian TLR1, TLR2, TLR6, and TLR10); and (2) a clade including the remainder of mammalian TLRs. Correlating data on ligand type, subcellular localization, and gene...

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Source

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Identifiers

PMID: 18415094
DOI: 10.1007/s00251-008-0283-5
PMCID: PMC2431982

Genes

TLR1
TLR10
TLR2
TLR6
TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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