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Emergence and evolution of <i>Plasmodium falciparum</i> histidine-rich protein 2 and 3 deletion mutant parasites in Ethiopia

2021-01-29

Abstract excerpt

Malaria diagnostic testing in Africa is threatened by Plasmodium falciparum parasites lacking histidine-rich protein 2 ( pfhrp2 ) and 3 ( pfhrp3 ) genes. Among 12,572 subjects enrolled along Ethiopia’s borders with Eritrea, Sudan, and South Sudan and using multiple assays, we estimate HRP2-based rapid diagnostic tests would miss 9.7% (95% CI 8.5-11.1) of falciparum malaria cases due to pfhrp2 deletion. Established...

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Literature Corpus work
d976ec7a-f292-5911-9b9c-a0ba15d4507d
DOI
10.1101/2021.01.26.21250503
Open publication

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Emergence and evolution of <i>Plasmodium falciparum</i> histidine-rich protein 2 and 3 deletion mutant parasites in EthiopiaDOI 10.1101/2021.01.26.21250503
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