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Novel Plasmodium falciparum histidine-rich protein 2/3 repeat type in Ethiopian malaria infection: does this affect performance of HRP2-based malaria RDT?

Malaria journal - 29 Aug 2024

Mandefro Aynalem, Kebede Alebachew Messele, Mekonen Bacha, Katsvanga Mitchel, Cham Fatoumatta, Etoketim Blessed, Oriero Eniyou, Amambua-Ngwa Alfred, Golassa Lemu

Abstract excerpt

BACKGROUND: Rapid diagnostic tests (RDTs) provide quick, easy, and convenient early diagnosis of malaria ensuring better case management particularly in resource-constrained settings. Nevertheless, the efficiency of HRP2-based RDT can be compromised by Plasmodium falciparum histidine-rich protein 2/3 gene deletion and genetic diversity. This study explored the genetic diversity of PfHRP2/3 in uncomplicated...

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Identifiers

PMID: 39210318
DOI: 10.1186/s12936-024-05093-9
PMCID: PMC11360870

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