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High prevalence and extended deletions in Plasmodium falciparum hrp2/3 genomic loci in Ethiopia

5 Nov 2020

Abstract excerpt

Deletions in Plasmodium falciparum histidine rich protein 2(pfhrp2) gene threaten the usefulness of the most widely used HRP2-based malaria rapid diagnostic tests (mRDTs) that cross react with its structural homologue, PfHRP3. Parasites with deleted pfhrp2/3 genes remain undetected and untreated due to 'false-negative' RDT results. As Ethiopia recently launched malaria elimination by 2030 in certain selected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33152025
DOI: 10.1371/journal.pone.0241807

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