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Article

Deletion of target gene (histidine-rich protein 2/3) for Plasmodium falciparum rapid diagnostic tests in Amhara region, Ethiopia: a cross-sectional study

2 Aug 2025

Abstract excerpt

BACKGROUND: Plasmodium falciparum histidine-rich protein 2 (pfhrp2)-based rapid diagnostic tests (RDTs) have been instrumental in enhancing malaria surveillance and case management, especially in Africa where P. falciparum predominates. However, the emergence of pfhrp2/3 gene deletions poses a serious threat to their effectiveness. Therefore, regular monitoring of pfhrp2/3 deletion status at both local and...

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PMID: 40753217
DOI: 10.1186/s12936-025-05485-5

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