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Article

Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia.

Nature microbiology - 1 Oct 2021

Feleke Sindew M, Reichert Emily N, Mohammed Hussein, Brhane Bokretsion G, Mekete Kalkidan, Mamo Hassen, Petros Beyene, Solomon Hiwot, Abate Ebba, Hennelly Chris, Denton Madeline, Keeler Corinna, Hathaway Nicholas J, Juliano Jonathan J, Bailey Jeffrey A, Rogier Eric, Cunningham Jane, Aydemir Ozkan, Parr Jonathan B

Abstract excerpt

In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) and 3 (pfhrp3) genes escape detection by these RDTs, but it is not known whether these deletions confer sufficient selective advantage to drive rapid population expansion. By studying blood samples from a cohort of 12,572...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34580442
DOI: 10.1038/s41564-021-00962-4
PMCID: PMC8478644

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