Article
In Vitro Drug Screening Using iPSC-Derived Cardiomyocytes of a Long QT-Syndrome Patient Carrying KCNQ1 & TRPM4 Dual Mutation: An Experimental Personalized Treatment.
Cells - 11 Aug 2022
Wang Feifei, Han Yafan, Sang Wanyue, Wang Lu, Liang Xiaoyan, Wang Liang, Xing Qiang, Guo Yankai, Zhang Jianghua, Zhang Ling, Zukela Tuerhong, Xiaokereti Jiasuoer, Lu Yanmei, Zhou Xianhui, Tang Baopeng, Li Yaodong
Abstract excerpt
Congenital long QT syndrome is a type of inherited cardiovascular disorder characterized by prolonged QT interval. Patient often suffer from syncopal episodes, electrocardiographic abnormalities and life-threatening arrhythmia. Given the complexity of the root cause of the disease, a combination of clinical diagnosis and drug screening using patient-derived cardiomyocytes represents a more effective way to...
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