Article

Increased L-type calcium current causes action potential prolongation in Jervell and Lange-Nielsen syndrome and is a drug target

2025-03-21

Abstract excerpt

<h4>Background</h4> KCNQ1 loss of function variants are thought to cause type 1 long QT syndrome by reducing I Ks . However, we have recently reported that pharmacologic block of I Ks in human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) produced minimal increases in action potential duration at 90% repolarization (APD 90 ), while genetic loss of KCNQ1 markedly prolonged APD 90 . We sought here...

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Literature Corpus work: 151b46e0-f1f2-5349-8b08-e9768de203b7
DOI: 10.1101/2025.03.20.25324224

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