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Article

Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome.

Biochemical and biophysical research communications - 1 Oct 2021

Giacomelli Elisa, Sala Luca, Oostwaard Dorien Ward-van, Bellin Milena

Abstract excerpt

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) and their derivative cardiomyocytes (hiPSC-CMs) have been successfully used to study the electrical phenotype of cardiac ion channel diseases. However, strategies to mature CMs and more comprehensive systems recapitulating the heart complexity are required to advance our ability to capture adult phenotypes. METHODS: We differentiated wild-type (WT) and...

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Identifiers

PMID: 34364290
DOI: 10.1016/j.bbrc.2021.07.068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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