Article

Mitochondrial dysfunction in Machado Joseph Disease: insights from a multi-model system

2025-05-02

Abstract excerpt

Spinocerebellar ataxia type-3 (SCA3), also known as Machado Joseph disease, MJD) is a fatal, neurodegenerative disease belonging to the polyglutamine repeat disease family, caused by inheritance of an abnormal form of the ATXN3 gene, carrying a longer than usual trinucleotide repeat sequence. Within this study we explored mitochondrial function in a range of different experimental models of MJD, including transgen...

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Literature Corpus work: 6d9026fa-550e-5a24-af0e-94d7021e5870
DOI: 10.1101/2025.05.01.651800

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