Article

Blood <i>DDIT4</i> and <i>TRIM13</i> transcript levels mark the early stages of Machado-Joseph disease

2023-10-03

Abstract excerpt

Machado-Joseph disease (MJD) is a rare late-onset polyglutamine neurodegenerative disease caused by the expansion of a CAG repeat in the ATXN3 gene encoding the ataxin- 3 (ATXN3) protein. Several studies have identified changes in the abundance of select transcripts and proteins in blood samples of MJD mutation carriers. Here, we aimed to: 1) identify blood transcriptional changes that could be potential biomarke...

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Literature Corpus work: 25a8c422-8ec0-5b6a-9905-5f71c6c805cd
DOI: 10.1101/2023.10.01.560372

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