Article

Oligodendrocytes depend on MCL-1 to prevent spontaneous apoptosis and white matter degeneration

2020-12-03

Abstract excerpt

Neurologic disorders often disproportionately affect specific brain regions, and different apoptotic mechanisms may contribute to white matter pathology in leukodystrophies or gray matter pathology in poliodystrophies. We previously showed that neural progenitors that generate cerebellar gray matter depend on the anti-apoptotic protein BCL-xL. Conditional deletion of Bcl-xL in these progenitors produces spontaneo...

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Literature Corpus work: a22c99fa-342f-5b6c-9274-5702fc5c8e62
DOI: 10.1101/2020.12.02.408138

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