Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptosis in mitochondrial encephalomyopathies with mitochondrial DNA mutations: a potential pathogenic mechanism.

Brain : a journal of neurology - 1 Jan 2000

Mirabella M, Di Giovanni S, Silvestri G, Tonali P, Servidei S

Abstract excerpt

Mitochondrial encephalomyopathies caused by mitochondrial DNA (mtDNA) defects are a genetically and phenotypically heterogeneous group of disorders. The site, percentage and distribution of mutations do not explain the overall clinical heterogeneity that is found. Apoptosis (programmed cell death) is an evolutionarily conserved mechanism that is essential for tissue development and homeostasis. Dysregulation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inclusion Bodies
Share to MELAS Syndrome
Share to MERRF Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Encephalomyopathies

Share to Muscle, Skeletal

Share to Point Mutation

Share to Sequence Deletion

Source

Identifiers

PMID: 10611124
DOI: 10.1093/brain/123.1.93

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptosis in mitochondrial encephalomyopathies with mitochondrial DNA mutations: a potential pathogenic mechanism.PMID 10611124Read ↗

Evidence of apoptosis via TUNEL staining in muscle biopsy from patients with mitochondrial encephaloneuromyopathies.Semantic proximity Read ↗

Lack of apoptosis in mitochondrial encephalomyopathies.Semantic proximity Read ↗

Apoptosis in neurodegenerative diseases: the role of mitochondriaSemantic proximity Read ↗

Role of reactive oxygen species-elicited apoptosis in the pathophysiology of mitochondrial and neurodegenerative diseases associated with mitochondrial DNA mutations.Semantic proximity Read ↗

The role of apoptosis in neuromuscular diseases and prospects for anti-apoptosis therapy.Semantic proximity Read ↗

Apoptosis and Oxidative Stress in Neurodegenerative DiseasesSemantic proximity Read ↗

Apoptosis in amyotrophic lateral sclerosis: a review of the evidenceSemantic proximity Read ↗

MtDNA mutations in aging and apoptosis.Semantic proximity Read ↗

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations.Semantic proximity Read ↗

Muscle Apoptotic Response to Denervation, Disuse, and AgingSemantic proximity Read ↗

Mitochondria in Skeletal MuscleSemantic proximity Read ↗

Mutations in apoptosis genes: a pathogenetic factor for human disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.