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High-throughput single-cell activity-based screening and sequencing of antibodies using droplet microfluidics

30 Mar 2020

Abstract excerpt

Mining the antibody repertoire of plasma cells and plasmablasts could enable the discovery of useful antibodies for therapeutic or research purposes1. We present a method for high-throughput, single-cell screening of IgG-secreting primary cells to characterize antibody binding to soluble and membrane-bound antigens. CelliGO is a droplet microfluidics system that combines high-throughput screening for IgG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32231335
DOI: 10.1038/s41587-020-0466-7

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