Article

Replacement of a single residue in an antibody completely abolishes cognate antigen binding, as predicted by theoretical methods

2025-06-30

Abstract excerpt

Structural insights into the interaction between antibodies and antigens at the atomic level are pivotal for understanding the molecular mechanisms of antigen binding. Despite the availability of structural models generated by recent artificial intelligence advancements, computational predictions require experimental validation to confirm their accuracy. Here, we demonstrate a novel approach that combines computat...

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Literature Corpus work: d964df2c-665a-59e9-aa84-01eff4c11729
DOI: 10.1101/2025.06.26.661714

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