Article

Impact of Human Genetic Variation Underlying Resistance to Antigen-Specific Immunotherapy

2025-05-07

Abstract excerpt

Monoclonal antibodies have transformed the therapeutic landscape across oncology, immunology, and infectious diseases by enabling high-affinity, antigen-specific targeting, e.g. to neutralize soluble molecules, block cellular interactions or deplete cells. While high specificity is critical for safety, it may confer an inherent susceptibility to even minor variations within the target epitope. Here, we present the...

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Literature Corpus work: 0a97b029-c95c-5407-ba85-1f35125ef98d
DOI: 10.1101/2025.05.02.651174

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