Article
Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1 alpha.
Disease models & mechanisms - 1 Apr 2026
Hoyle Christopher, Pino Rodrigo Díaz, Lai Si Min, Green Jack P, Adamson Antony, Coutts Graham, Lawrence Catherine B, Travis Mark, Brough David, Lopez-Castejon Gloria
Abstract excerpt
Interleukin (IL)-1α is a pro-inflammatory member of the IL-1 cytokine superfamily and is important for inflammatory responses to infection and injury. Unlike pro-IL-1β, pro-IL-1α is mainly localised to the nucleus upon expression. This is mediated by a nuclear localisation sequence (NLS) responsible for its importin-dependent transport into the nucleus. This nuclear localisation and the presence of histone acetyl...
Topics
Join the communities discussing this publication.