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Article

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.

Cells - 22 Oct 2020

Iannotta Lucia, Biosa Alice, Kluss Jillian H, Tombesi Giulia, Kaganovich Alice, Cogo Susanna, Plotegher Nicoletta, Civiero Laura, Lobbestael Evy, Baekelandt Veerle, Cookson Mark R, Greggio Elisa

Abstract excerpt

Mutations in LRRK2 cause familial Parkinson's disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which impacts downstream phosphorylation of its substrates, among which Rab10. A comprehensive characterization of LRRK2 activity and phosphorylation in brain as a function of age and...

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Identifiers

PMID: 33105882
DOI: 10.3390/cells9112344
PMCID: PMC7690595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues.PMID 33105882Read ↗

LRRK2 Phosphorylation: Behind the Scenes.Semantic proximity Read ↗

LRRK2 exonic variants associated with Parkinson’s disease augment phosphorylation levels for LRRK2-Ser1292 and Rab10-Thr73Semantic proximity Read ↗

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sitesSemantic proximity Read ↗

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.Semantic proximity Read ↗

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activitySemantic proximity Read ↗

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.Semantic proximity Read ↗

Parkinson’s disease-associated LRRK2 risk variant, G2385R, enhances Rab substrate phosphorylation and impairs neuronal integritySemantic proximity Read ↗

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.Semantic proximity Read ↗

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.Semantic proximity Read ↗

Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson’s diseaseSemantic proximity Read ↗

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPasesSemantic proximity Read ↗

Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's diseaseSemantic proximity Read ↗

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