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<i>BACE</i> Maps to Chromosome 11 and a <i>BACE</i> Homolog, <i>BACE2</i> , Reside in the Obligate Down Syndrome Region of Chromosome 21

1999-11-12

Abstract excerpt

Abundant deposition of amyloid-β (in senile plaques) is a key neuropathological hallmark of Alzheimer's disease (AD). The major component of plaques is the 39– to 43–amino acid amyloid-β peptide. Amyloid-β is generated via proteolytic processing of the amyloid precursor protein (APP) by two

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Literature Corpus work
d8f5c19d-8a60-5d72-bbb1-30e465354220
DOI
10.1126/science.286.5443.1255a
Open publication

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<i>BACE</i> Maps to Chromosome 11 and a <i>BACE</i> Homolog, <i>BACE2</i> , Reside in the Obligate Down Syndrome Region of Chromosome 21DOI 10.1126/science.286.5443.1255a
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