Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein.

Aging - 9 Jan 2020

Gomez Wileidy, Morales Rodrigo, Maracaja-Coutinho Vinicius, Parra Valentina, Nassif Melissa

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent type of dementia. Down syndrome (DS) is the leading genetic risk factor for Early-Onset AD, prematurely presenting the classic pathological features of the brain with AD. Augmented gene dosage, including the APP gene, could partially cause this predisposition. Recent works have revealed that alterations in chromosome location due to the extra Chromosome 21, as well...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Autophagy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Down Syndrome

Share to Oxidative Stress

Share to Protein Aggregation, Pathological

Share to Proteolysis

Share to RNA, Untranslated

Source

Open in PubMed Open full text

Identifiers

PMID: 31918411
DOI: 10.18632/aging.102677
PMCID: PMC6977673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein.PMID 31918411Read ↗

Aging in Down Syndrome and the Development of Alzheimer's Disease NeuropathologySemantic proximity Read ↗

Common genetic signatures of Alzheimer’s disease in Down SyndromeSemantic proximity Read ↗

From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approachSemantic proximity Read ↗

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.Semantic proximity Read ↗

Aging with Down Syndrome—Where Are We Now and Where Are We Going?Semantic proximity Read ↗

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down SyndromeSemantic proximity Read ↗

Down syndrome and Alzheimer's disease: A link between development and agingSemantic proximity Read ↗

Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like DementiaSemantic proximity Read ↗

Mechanistic Analysis of Age-Related Clinical Manifestations in Down SyndromeSemantic proximity Read ↗

The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.Semantic proximity Read ↗

Signalling Pathways Implicated in Alzheimer′s Disease Neurodegeneration in Individuals with and without Down SyndromeSemantic proximity Read ↗

Beta-amyloid, oxidative stress and down syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.