Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Abstract excerpt

Individuals who have Down syndrome (DS) frequently develop early onset Alzheimer9s disease (AD), a neurodegenerative condition caused by the buildup of aggregated amyloid-β (Aβ) and tau proteins in the brain. Aβ is produced by amyloid precursor protein (APP), a gene located on chromosome 21. People who have DS have three copies of chromosome 21 and thus also an additional copy of APP; this genetic change drives...

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